Neisseria

• Gram negative Diplococcus

Neisseria menigitidis

• Meningococcus
• Enter via nasopharnyx
• Travel via blood stream
• Bacteraemia produces
  • High fever
  • Haemorrhagic rash
• May lead to
  • Waterhouse-Friedrichson Syndrome
    • Sepsis & DIC
    • Circulatory collapse
• Common complication is Meningitis
• Rapid onset & progression
• Sensitive to Penicillin G

Neisseria Gonorrhoeae

• Gonococcus
• Attach to surface epithelial cells
• Attack mucous membranes of
  • Genitourinary Tract & Rectum
  • Eye & Throat
• Produces suppuration
• Leads to
  • Urethritis in males
  • PID in females
• May progress to tissue invasion
• Bacteraemia leads to
  • Haemorrhagic skin pustules
  • Arthritis in knees, ankles & wrists
• Commonly causes septic arthritis & OM in USA
• Most serious infections sensitive to Penicillin G
• Gradual rise in resistance to Penicillin G
  • Treat with Tetracycline