Cervical Myelopathy

Video

Western Health Orthopaedic Registrar presentation – Cervical Spondylosis, Radiculopathy & Myelopathy by Dr James Churchill

Definition

  • Spinal cord dysfunction
    • Demyelination of the lateral columns with degeneration of the anterior parts of the posterior columns
    • Destruction of the central grey matter

Epidemiology

  • Most common spinal cord dysfunction in patients > 55 years old

Aetiology

  • Extrinsic compression of cord (or its vascular supply or both) caused by degenerative disease of spine

Pathology

  • Maybe associated with congenital or developmental stenosis of the cervical canal
  • Disc degenerates
  • Secondary osteoarthritic changes occur in the facet & uncovertebral joints
  • Reduction of available space
  • Ligamentum Flavum invaginates into canal posteriorly
  • Disc & posterior vertebral body osteophytes encroach anteriorly – Pincher action

Differential Diagnosis

  • CVD
  • AV malformation
  • Demyelinating disease
  • Syringomyelia
  • Intracranial tumor
  • Hydrocephalus
  • Tabes dorsalis
  • Myopathy
  • Peripheral neuropathy
  • Metabolic or alcoholic encephalopathy

History

  • Neck pain
  • Difficulty walking
  • Unsteadiness on feet
  • Pain , numbness & weakness with clumbsiness of hands common
  • May also have radicular symptoms
  • Bladder dysfunction uncommonly occurs
  • co existent lumbar stenosis common

Examination

  • UMN in extremites below lesion & LMN signs at level of lesion
  • Can see UMN signs cephalad to lesion
  • Hoffman Reflex
    • Flexion of ipsilateral IPJ of index & thumb when long finger IPJ flicked & extension of neck ↑ sensitivity
  • Inverted Radial Reflex
    • Spontaneous flexion of digits when BR reflex elicited & indicates cord compression at C5 & C6 (commonest levels)
  • L’Hermitte sign
    • Flexion or extension of neck produces electric shock sensations in legs
  • Abnormal Plantar reflexes
    • Usually only abnormal when severe
  • Earliest sensory changes are dysdiadochokinesia & poor tandem gait
    • Vibration & Joint position sense affected early
    • Weakness & loss of proprioception leads to Wide Based Gait
    • Finger Escape Sign – deficient adduction or extension of ulnar digits of affected hand

Investigations

XRs

  • Narrowed joint space
  • C5/6 commonest level followed by C6/7
  • Osteophytic lipping with foraminal & uncovertebral osteophytes seen
  • Lateral may showListhesis
  • Lordosis
  • Kyphosis
  • Flexion / Extension views show instabilty
  • Pavlovs Ratio (A-P diameter of spinal canal divided by the A-P diameter of body at same level) indicator of developmental stenosis
  • Should be 1.0 & < 0.8 is narrowed & stenotic
  • diameter (A-P) reduced from normal ( 17mm) to relative ( 13mm) to absolute stenosis ( 10mm)
  • Remember that 70% of population have degenerative changes by 70 year

MRI

  • Evaluate soft tissues of the cord
  • High incidence or asymptomatic findings – 19% of asymptomatic patients have abnormality on MRI
  • Disc prolapse & cord oedema with signal change seen

CT – Myelography

  • Helps distinguish disc from osteophytes
  • Superior for cord compression due to subluxed body & ossification of the PLL
  • transverse diameter of cord at affected level on CT – Myelogram shown to be best prognostic indicator in spondylitic stenosis & ossification of PLL

Treatment

  • Natural history
    • suggests that > 50% of patients become worse if not treated
  • best spinal cord recovery seen in those treated with:
    • Decompression within 6 – 12 months
    • Early , mild myelopathic signs
    • Those whose transverse area of cord greater than 40 mm 2 postoperatively

Non operative

  • Cervical collar
  • Nsaids
  • Physiotherapy with isometric strengthening
  • Ice , heat & massage
  • Follow up every 6-12 weeks initially followed by yearly if no progression
  • Traction & manipulation contraindicated

Operative

  • Absolute Indications
    • Progressive neurological deficit
    • Failure to improve with 6 /12 of non op treatment
    • Should try to operate prior to
      • Compression ratio < 0.4
      • Transverse spinal cord diam of < 40 mm2
      • Increased signal intensity of cord T2 MRI
    • patient with cervical & lumbar stenosis should have the cervical spine decompressed first because:
      • Risk of intubation damage to Cx spine reduced for lumbar surgery
      • Leg symptoms mat improve after the cervical decompression
  • Preoperative Considerations:
    • All NSAIDS ceased 2 weeks prior to surgery
    • Positioning should avoid hyperextension of cervical spine

Surgical Considerations

Positioning & Setup

  • Postioning for Anterior approach is
    • Supine with interscapular roll
    • Traction of 5 pounds
    • Head turned slightly to right for left sided approach to avoid rec laryngeal n
  • Positioning for the Posterior approach:
    • Prone
    • Mayfield head tongs in neutral
  • Should use the following ancillary devices:
    • Pneumatic compression stockings
    • IDC
    • Infiltration of skin with adrenaline solution

Bone Grafting Technique

  • Iliac crest autograft
    • prefered for the anterior interbody fusion rather than allograft
    • When > one segment fused then the failure of autograft was 17% cf 63% with allograft
    • iliac crest graft should be thick enough to provide at least 2mm more distraction than baseline disc height
    • Saw harvested tricortical grafts more strength than osteotome harvested

Soft Disc Herniation

  • Younger patients
  • Non op treatment often effective & indication for intervention include:
    • Failure of non op with >6 months of symptoms
    • Progressive myelopathy with correlative diagnostic studies
  • Important technical factors:
    • MRI reviewed carefully to exclude free disc lying behind the PLL
    • Should resect the disc until the longitudinal fibres of PLL seen & inspected carefully for defect
    • If no defect or MRI findings then should not routinely remove the PLL
  • Requirements for anterior approach include :
    • One , two or three level pathology
    • Pathology primarily at disc level
    • Anterior cord compression

Degenerative disc disease

  • Technical Factors:
    • Once disc removed the posterior body osteophytes removed
  • Disadvantages include
    • difficulty decompressing the nerve roots in foramen from front
    • difficult access to the posterior osteophytes
  • Cloward procedure allows better visualisation but risks include:
    • Fusion less stable
    • No distraction
    • Greater potential for collapse

One or two level Spondylosis with developmental narrowing of canal :

  • Pavlov ratio 0.8 to 1.0 Anterior approach favoured
  • if continued symptoms post-op & no ↑ in cord diameter then consider posterior laminectomy & fusion

Lesions of two or more levels:

  • Prefered treatment is anterior vertebrectomy & strut grafting
    • this leads to better outcome of fusion over large number of motion segments
  • Can Never consider posterior decompression if the patient has kyphotic spine

Technical factors:

  • Lateral borders of body preserved
  • If > 7cm could consider vascularised fibula graft
  • Postop Halo immobilsation can minimise the risks of :
    • Graft dislodgement
    • Spinal malaignment
    • Pseudoarthrosis

Instability & Cervical Spondylitic Myelopathy:

  • If severe instabilty with kyphosis then combined anterior & posterior procedures used
  • Anterior Decompression & Arthrodesis
    • Maintain physiological lordosis
  • Instrumentation can :
    • Maintain alignment
    • Improve graft stability
    • Eliminate need for halo in selected patients

The use of posterior laminectomy over anterior considered in :

  • Technical limitations of anterior approach
  • Prior anterior surgery
  • Lordotic cervical spine

Ossification of the PLL:

  • Very common in asian population
  • 50% have associated DISH
  • Multiple levels usually involved with CT evidence best
  • Recommended procedure is posterior decompression
  • With the Anterior approach the dura may be absent or attached firmly to the dura & result in irreperable tears with CSF leaks
  • if Kyphosis present then should perform anterior decompression

Complications

Prognosis

References