Septic Arthritis in Children

Written by

Dr Emily Kong
MBBS | Accredited Orthopaedic Registrar

Weekly Presentation 26th March 2010

  • Septic arthritis must be ruled out in the child with a painful joint
  • Delay in treatment or failure to diagnose problematic
  • Difficult patient group to obtain history and examination
  • Prognosis significantly improved:
    • Mortality reduced from 50% in 1874 to <1% in 1974

Incidence

  • USA: 1 in 100,000 unchanged over a decade
  • Israel: 37 in 100,000
  • Malawi: 1 in 5000
  • Africa: 1 in 20,000

Causative Organisms

  • Most common: Staph aureus
  • Group A Strep, Enterobacter
  • H. influenza
    • significantly decreased by vaccination
  • Salmonella
    • common in children with sickle-cell disease
  • Kingella kingae
    • unusual
  • Beware emergence of MRSA

Risk factors

  • Young age
  • Male gender
  • Increased susceptibility to infection
  • Umbilical artery catheterization

Clinical symptoms and signs

  • Painful, swollen joint
  • Effusion
  • Restricted ROM
  • Tenderness
  • Increased warmth
  • Systemically unwell, irritability, fever
  • Cellulitis or abscess formation
  • Limited spontaneous movement of affected joint

Investigations

Laboratory

  • WCC
    • Usually elevated in older children,
    • sometimes elevated in younger children,
    • rarely elevated in neonates
  • ESR
    • alone sensitivity 79%
    • with elevated temp, elevated WCC and NWB – 98%
  • CRP
    • highest predictive value for septic arthritis

Imaging

  • Plain XR
    • Differential Diagnosis
      • osteomyelitis,
      • fracture,
      • neoplasia,
    • increased joint space may indicate effusion
  • Ultrasound
    • most sensitive tool for detection of hip effusion,
    • false negative rate 5%,
    • guided aspiration
      • can evacuate pus,
      • decrease damage to articular surfaces,
    • DDx other arthridities
    • direct ABx Rx,
    • caution with –ve US with symptoms <24hrs or bilateral disease
  • MRI
    • sensitive and specific, can differentiate from osteomyelitis and non-infective causes of hip pain,
    • signal intensity alterations and contrast enhancement of bone marrow and adjacent soft tissue
  • Bone scan
    • lacks sensitivity and specificity

Treatment

Management algorithms

  • Attempt to improve diagnosis and treatment
  • Not applicable in all settings
  • Should supplement, not substitute, clinical decision-making

Antibiotics

  • Wide support for early administration and not withheld before diagnoseif clinical suspicion
  • Choice based on most likely organism
  • Initially administer i/v, then oral when clinical improvement evident
  • Debate on duration of i/v: 2-7wks
  • Growing evidence for short-course i/v therapy – 7 days

Joint Aspiration Vs Arthrotomy + Washout

  • Arthrotomy best method of Rx
  • Doubt with adequacy of decompression achieved with U/S guided aspiration
  • Repeat aspirations may be required
  • Only significant difference in open Vs arthroscopic hip washout was shortened inpatient stay

Take home message

  • Indicators of poor prognosis:
    • Young age:
      • difficult to Dx, transphyseal vessels in neonates
    • Delay in initiating Rx:
      • if diagnose delayed by >4 days
        • Excellent outcome in only 15%
    • Organism
      • Staph aureus highly virulent
    • Site
      • worst outcome in hip